Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry.
By A. Hirayama, K. Kami, Masahiro Sugimoto, M. Sugawara, N. Toki, Hiroko Onozuka, T. Kinoshitá, N. Saitō, A. Ochiai, Masaru Tomita and 2 more. Cancer Research, 2009
909 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology, Spectroscopy
View Paper: https://www.semanticscholar.org/paper/ca2677418a5602908a2407b0ca22740fc0b9f4e5
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In Cancer Research
In Molecular Biology
- David M. Sabatini
- Arkaitz Carracedo
- P. Pandolfi
- Tim Wang
- Walter W. Chen
- Masahiro Sugimoto
- David T. W. Wong
- Daniel K. Manter
Citations in the corpus
- SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization (2011, background): “…(KO) MEFs demonstrated a clear shift toward glycolytic metabolism when compared with SIRT3 wild-type (WT) counterparts (Figure 1A), similar to the metabolic shift reported for transformed cells in culture (Lu et al., 2010) and for cancer cells in vivo (Denkert et al., 2008; Hirayama et al., 2009).”
- Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides (2014, background): “We considered two explanations for why low glucose sensitive lines do not substantially increase oxygen consumption upon glucose limitation: (1) a defect in glucose utilization that limits substrates for mitochondria, or (2) a defect in OXPHOS itself.”
- Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles (2009, methodology): “Several metabolites in tumor tissues, such as lactate, which is derived from tumor exposed to hypoxia, were altered both with and without metastasis (Hirayama et al. 2009; Walenta et al. 2000).”
- Stool Microbiome and Metabolome Differences between Colorectal Cancer Patients and Healthy Adults (2013, background): “An increased concentration of all amino acids except glutamine was previously reported in stomach and colon tumor tissues compared to healthy tissue [42].”
- Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches (2019, background): “Cancer cells are avid consumers of glucose, however, intratumoral levels of glucose are usually exceedingly low (51).”