Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus

By T. Foster, J. Geoghegan, V. Ganesh, M. Höök. Nature Reviews Microbiology, 2013

1,430 citations recorded by the source corpus.

Staphylococcus aureus is an important opportunistic pathogen and persistently colonizes about 20% of the human population. Its surface is 'decorated' with proteins that are covalently anchored to the cell wall peptidoglycan. Structural and functional analysis has identified four distinct classes of surface proteins, of which microbial surface component recognizing adhesive matrix molecules (MSCRAMMs) are the largest class. These surface proteins have numerous functions, including adhesion to and invasion of host cells and tissues, evasion of immune responses and biofilm formation. Thus, cell wall-anchored proteins are essential virulence factors for the survival of S. aureus in the commensal state and during invasive infections, and targeting them with vaccines could combat S. aureus infections.

Subfields: Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c9e04581456823d03313e2fdb8ec643fcd0e61b4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. Jessica L. Lister
2. G. Peters
3. K. Becker
4. A. Horswill
5. Christine Heilmann

In Molecular Biology

1. Jessica L. Lister
2. G. Peters
3. K. Becker
4. A. Horswill
5. Christine Heilmann

Citations in the corpus

• Staphylococcus aureus biofilms: recent developments in biofilm dispersal (2014, background): “Attachment is mediated through surface proteins, referred to as microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) (Foster et al., 2014).”
• Coagulase-Negative Staphylococci (2014, methodology): “According to this classification, the use of the term “MSCRAMM” should now be restricted to those CWA proteins that possess at least two adjacently located IgG-like folded domains in their Nterminal A portion that bind their ligands via the “dock, lock, and latch” mechanism (237).”
• The wound microbiota: microbial mechanisms of impaired wound healing and infection (2024, neutral): “These proteins recognize extra-cellular matrix components (collagen, laminin, elastin) as well as glycoproteins that are exposed when the skin barrier is broken, of which fibronectin has been extensively studied 48 .”