Staphylococcus aureus biofilms: recent developments in biofilm dispersal
By Jessica L. Lister, A. Horswill. Frontiers in Cellular and Infection Microbiology, 2014
610 citations recorded by the source corpus.
Staphylococcus aureus is a major cause of nosocomial and community-acquired infections and represents a significant burden on the healthcare system. S. aureus attachment to medical implants and host tissue, and the establishment of a mature biofilm, play an important role in the persistence of chronic infections. The formation of a biofilm, and encasement of cells in a polymer-based matrix, decreases the susceptibility to antimicrobials and immune defenses, making these infections difficult to eradicate. During infection, dispersal of cells from the biofilm can result in spread to secondary sites and worsening of the infection. In this review, we discuss the current understanding of the pathways behind biofilm dispersal in S. aureus, with a focus on enzymatic and newly described broad-spectrum dispersal mechanisms. Additionally, we explore potential applications of dispersal in the treatment of biofilm-mediated infections.
Subfields: Infectious Diseases, Microbiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/79dd8d4ab9828871c94cae9d1d29c17a50f22a32
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In Molecular Biology
Citations in the corpus
- Bacterial biofilm formation on implantable devices and approaches to its treatment and prevention (2018, background): “Attachment is characterized by the production of bacterial adhesins that stick to the surface, while cell-cell adhesion mechanisms mediate maturation, and enzymes that degrade the biofilm matrix mediate dispersal [69, 70, 71].”