Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease.
By S. Tedelind, Fredrik Westberg, M. Kjerrulf, Alexander Vidal. World Journal of Gastroenterology, 2007
807 citations recorded by the source corpus.
AIM To compare the anti-inflammatory properties of butyrate with two other SCFAs, namely acetate and propionate, which have less well-documented effects on inflammation. METHODS The effect of SCFAs on cytokine release from human neutrophils was studied with ELISA. SCFA-dependent modulation of NF-kappaB reporter activity was assessed in the human colon adenocarcinoma cell line, Colo320DM. Finally, the effect of SCFAs on gene expression and cytokine release, measured with RT-PCR and ELISA, respectively, was studied in mouse colon organ cultures established from colitic mice. RESULTS Acetate, propionate and butyrate at 30 mmol/L decreased LPS-stimulated TNFalpha release from neutrophils, without affecting IL-8 protein release. All SCFAs dose dependently inhibited NF-kappaB reporter activity in Colo320DM cells. Propionate dose-dependently suppressed IL-6 mRNA and protein release from colon organ cultures and comparative studies revealed that propionate and butyrate at 30 mmol/L caused a strong inhibition of immune-related gene expression, whereas acetate was less effective. A similar inhibition was achieved with the proteasome inhibitor MG-132, but not the p38 MAPK inhibitor SB203580. All SCFAs decreased IL-6 protein release from organ cultures. CONCLUSION In the present study propionate and butyrate were equipotent, whereas acetate was less effective, at suppressing NF-kappaB reporter activity, immune-related gene expression and cytokine release in vitro. Our findings suggest that propionate and acetate, in addition to butyrate, could be useful in the treatment of inflammatory disorders, including IBD.
Subfields: Genetics, Immunology, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/c9cf2550fe656a787ae7d5023cac7a9e5ae7a79d
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Citations in the corpus
- Regulation of Inflammation by Short Chain Fatty Acids (2011, background): “Acetate, propionate and butyrate at 30 mM reduce TNF-α production by LPS-stimulated human neutrophils [62].”
- Postbiotics—A Step Beyond Pre- and Probiotics (2020, background): “Propionate also shows an anti-inflammatory activity effect in vivo that is comparable to that of butyrate [51].”
- Gut Microbiota and Immune System Interactions (2020, background): “Acetate also plays an anti-inflammatory role in neutrophils by reducing NF-kB activation via inhibiting the expression of pro-inflammatory mediators such as lipopolysaccharide-induced TNF-α, though to a lesser degree than propionate or butyrate [23,24].”
- Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment (2012, background): “Butyrate in particular is a major source of energy for colonocytes, but all three of these have demonstrated immunomodulatory properties [22-27].”
- Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils. (2011, background): “The only study that focused on this aspect reported reduction of TNF-α production by lipopolysaccharide (LPS)-stimulated neutrophils in the presence of SCFAs [18].”