The cap-to-tail guide to mRNA turnover

By C. Wilusz, Michael Wormington, S. Peltz. Nature reviews. Molecular cell biology, 2001

807 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c9779ed103328e5761aad476538549c21d76db04

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In Molecular Biology

Min Wu

Citations in the corpus

Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. (2003, background): “Perturbation of this closed loop conformation predisposes to decapping and the accelerated mRNA decay and also impairs translation efficiency by decreasing recruitment of the 40S ribosome subunit (42,43).”
mRNA-based therapeutics: powerful and versatile tools to combat diseases (2022, background): “The 5′ cap protects mRNA from 5′ to 3′ exoribonucleases,(27) and the length of the poly(A) tail determines the 3′ to 5′ exonucleolytic decay.(28) Based on the vital importance of these functional elements, numerous studies have focused on the optimization of mRNA structure, such as developing a seri”
MyD88-mediated stabilization of interferon-γ-induced cytokine and chemokine mRNA (2006, neutral): “However, it is apparent that post-transcriptional control of gene expression is importan”
Advance Publication by J-STAGE Japanese Journal of Infectious Diseases Isolation of human coronaviruses OC43, HKU1, NL63, and 229E in Yamagata, Japan, using primary human airway epithelium cells cultured by employing an air-liquid interface culture (2020, neutral): “These modifications are carried out in the nucleus and have 100 critical roles in the export of mRNAs into the cytoplasm, translational regulation, and 101 mRNA decay [13-15].”
AU-rich elements and associated factors: are there unifying principles? (2006, background): “Identification of ARE-BPs and analysis of their contributions to the AREdependent degradation of targeted mRNAs started 15 years ago and is still continuing [reviewed in (27,43,44)].”