Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment.

By A. Hrõbjartsson, P. Gøtzsche. New England Journal of Medicine, 2001

1,500 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Complementary and alternative medicine, Philosophy

View Paper: https://www.semanticscholar.org/paper/c96790469cae2eb56a906f033c114f7add4a3c38

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Citations in the corpus

Influence of Reported Study Design Characteristics on Intervention Effect Estimates From Randomized, Controlled Trials (2012, result): “Associations of lack of or unclear double-blinding with exaggeration of intervention effect estimates and increases in between-trial heterogeneity in trials with subjectively assessed outcome measures are consistent with there being more prominent placebo effects, or biased outcome assessment, in su”
Longitudinal benefit of positive self-perceptions of aging on functional health. (2002, background): “(A recent review of published placebo studies found that there was a significant effect on pain, but none on several other categories— which did not include those into which our two examples fall, Hrobjartsson & Gotzsche, 2001 .)”
Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study. (2010, background): “However, some of the apparent improvement may be due to a significant placebo effect known to be substantial in objective measures of physical parameters (32, 33).”
Placebo Effects: Biological, Clinical and Ethical Advances (2010, neutral): “Several meta-analyses have attempted to address the presence and magnitude of placebo effects in RCTs, including some studies in which no-treatment control groups were used.”
Deconstructing the Placebo Effect and Finding the Meaning Response (2002, background): “One widely reported study, which concluded that placebos were powerless (11), or represented the Wizard of Oz (12), occasioned a blizzard of criticism (13–26) and some support (27).”
Evidence-Based Practice: Counterarguments to Objections (2002, background): “Furthermore, the authors of a systematic review of clinical trials in which patients were randomly assigned to either placebo or no treatment concluded that there was little evidence that placebos had powerful clinical effects (Hrobjartsson & Gotzsche, 2001).”