Molecular aspects of thyroid hormone actions.

By Sheue-yann Cheng, J. L. Leonard, P. Davis. Endocrine reviews, 2010

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Mechanisms of thyroid hormone action. (2012, positive): “There are two TR genes, TR α and TR β , with different patterns of expression in development and in adult tissues (2, 13).”
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. (2012, neutral): “Many hormone receptors are expressed specifically in a single or a few cell types (for example, receptors for TSH are localized to the thyroid), whereas some (like thyroid hormone receptors) are found throughout the body (102).”
Thyroid hormone regulation of metabolism. (2014, background): “Each TR isoform has several splice products, for example, TR 1 and 2 and TR 1 and 2 (28, 40).”
Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014, positive): “While the traditional view has been that T3 is important as the main iodothyronine with significant binding to nuclear TRs at physiological concentrations, and T4 is important as a precursor of T3 (466), the use of desiccated thyroid extracts for therapy of hypothyroidism is based on the hypothesis ”