Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.

By Laura N. Vandenberg, T. Colborn, Tyrone B. Hayes, J. Heindel, David R. Jacobs, Duk-Hee Lee, Toshi Shioda, Ana M. Soto, F. V. vom Saal, W. Welshons and 2 more. Endocrine reviews, 2012

2,959 citations recorded by the source corpus.

Subfields: Cancer Research, Health, Toxicology and Mutagenesis, Small Animals

View Paper: https://www.semanticscholar.org/paper/36d36d88cdd1bb6df839dc96606eb0d1b9dfd4b8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. J. Rochester
2. W. Welshons
3. F. V. vom Saal
4. A. Mantovani

In Health, Toxicology and Mutagenesis

1. J. Rochester
2. W. Welshons
3. A. Proto
4. P. Bianco
5. Luigi Montano
6. M. Ricciardi
7. C. Pironti
8. O. Motta

In Small Animals

1. J. Rochester
2. W. Welshons
3. F. V. vom Saal

Citations in the corpus

• Bisphenol A and human health: a review of the literature. (2013, methodology): “Because the endocrine system 3 shows clear non-monotonic actions [2], it is not surprising that some of the effects seen in 4 humans followed a NMDRC.”
• Gender differences in autoimmune disease. (2014, neutral): “(Chighizola and Meroni, 2012; Pierdominici and Ortona, 2013; Vandenberg et al., 2012)).”
• Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement (2016, background): “Contemporary endocrine science has demonstrated that dose–response relationships will sometimes deviate from a linear increase in the frequency and severity of impacts expected as dose levels rise [19, 63].”
• EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. (2015, background): “In the study of EDCs, the term “low dose” is used in different ways, typically to distinguish studies that examine effects that are: 1) below the doses used in traditional toxicology studies, ie, doses below the no observed adverse effect level (NOAEL) or the low observed adverse effect level; 2) at”
• Developmental origins of non-communicable disease: Implications for research and public health (2012, background): “The most sensitive window for epigenetic effects is different for each tissue and may extend into early childhood and perhaps into puberty or beyond for some tissues such as the brain and the reproductive system [4,6].”
• Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes (2015, background): “Many in vivo BPA studies have demonstrated adverse outcomes at “low” (i.e., environmentally or physiologically relevant) doses (Vandenberg 2014a; Vandenberg et al. 2012).”
• Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society. (2012, background): “These observations are universally acknowledged by the endocrine community and have been extensively reviewed (13).”
• Teratogenic Effects of Glyphosate-Based Herbicides: Divergence of Regulatory Decisions from Scientific Evidence (2012, background): “A large body of evidence indicates that for some compounds, toxic effects are found at low doses but not at higher doses, and that different toxic effects can be found at different doses [28-31].”
• Endocrine-Disrupting Compounds: An Overview on Their Occurrence in the Aquatic Environment and Human Exposure (2021, background): “The NMDRC is defined as a nonlinear relationship between dose and effect, occurring where the slope of the dose–response curve changes sign somewhere within the range of doses examined [175].”
• Degradation of Pharmaceuticals and Personal Care Products by White-Rot Fungi—a Critical Review (2017, background): “For example, PPCPs such as synthetic hormones can induce endocrine disrupting effects on aquatic lives [6, 7].”
• A Framework for Assessing Effects of the Food System (2015, background): “Because of new research showing endocrine-disruptive activity at much lower levels of atrazine, the current limits are highly debated (Cragin et al., 2011; Hayes, 2004; Hayes et al., 2002; NRDC, 2010; Rohr and McCoy, 2010; Vandenberg et al., 2012).”
• Metabolism Disrupting Chemicals and Metabolic Disorders (2016, positive): “Other principles of hormone action are similarly expected for EDCs including their ability to induce tissue- and time-dependent effects and strong evidence that responses to EDCs can be non-monotonic (often referred to as biphasic or U-shaped responses) [5,210,215,218,219].”