Structure and function of long noncoding RNAs in epigenetic regulation

By Tim R. Mercer, John S. Mattick. Nature Structural &Molecular Biology, 2013

1,450 citations recorded by the source corpus.

Subfields: Cancer Research, Endocrinology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c8ff8e45460d19b6cb25da05e407045bcc66c599

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In Cancer Research

In Endocrinology

John S. Mattick

In Molecular Biology

Citations in the corpus

Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth (2014, background): “Noncoding RNAs can be divided in small (<200 nt) noncoding RNAs, which include microRNAs and transfer RNAs, and longer RNAs (>200 nt) include ribosomal RNAs and long noncoding RNAs (lncRNAs).(1,2) Although microRNAs are shown to play important roles in the post-transcriptional regulation of gene exp”
Comprehensive Genomic Characterization of Long Non-Coding RNAs across Human Cancers (2015, background): “Importantly, rapidly accumulating evidence indicates that lncRNAs are associated with chromatin-modifying complexes and guide epigenetic regulations in both physiological and pathological conditions (Mercer and Mattick, 2013).”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “Indeed, there is growing evidence of bifunctional transcripts serving both as protein templates and lncRNAs (64, 192).”
LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases (2018, background): “Over the past decade, associations between dysfunction of lncRNAs and diseases have been the subject of intense investigation (3).”
lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs (2014, background): “Among the heterogenous functions described, lncRNAs are capable of functioning as chromatin regulators (18,19), enhancer RNAs (20), nuclear scaffolds (21), snoRNA host genes (22), primary microRNA transcripts, pre-tRNAs, ceRNAs to sequester microRNAs (23) or the transcriptional machinery away from…”
Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets (2015, background): “In addition, they can also interact with proteins (to form scaffolds) and miRNAs (competing endogenous RNA) for an additional level of transcription regulation (Batista and Chang 2013; Mercer and Mattick 2013).”