Triggering and amplifying pathways of regulation of insulin secretion by glucose.

By J. Henquin. Diabetes, 2000

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Metabolomics for Investigating Physiological and Pathophysiological Processes. (2019, background): “This component of rapid, glucose-stimulated insulin secretion (GSIS) is called the “triggering pathway” (195).”
ATP-sensitive potassium channelopathies: focus on insulin secretion. (2005, background): “Glucose metabolism has additional effects on insulin release (5, 43), but under physiological conditions KATP channel closure is an essential step in stimulus-secretion coupling in β cells.”
PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. (2005, background): “In pancreatic -cells, intracellular cAMP signals generated by nutrient secretagogues are critical in regulating insulin secretion (226, 230, 231, 365, 433, 496, 524).”
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40 (2003, background): “Insulin is secreted from pancreatic β cells in response to elevated plasma glucose, with various factors modifying its secretio”