Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans

By A. Ellebedy, F. Krammer, Gui-Mei Li, Matthew S. Miller, C. Chiu, J. Wrammert, Cathy Y. Chang, C. Davis, Megan Mccausland, R. Elbein and 9 more. 2014

248 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

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Citations in the corpus

Potent Protection against H5N1 and H7N9 Influenza via Childhood Hemagglutinin Imprinting (2016, background): “S1), seem most consistent with a stemdirected mechanism for the antigenic seniority acting at the HA-group level (13).”
Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages (2018, unknown): “However, the exotic HA heads may 391 still be immunodominant and potentially interfere with or limit HA stem-specific responses as it 392 has been shown that transient vaccine-induced boost of the stem-directed antibody responses can 393 be replaced by immunodominant head-directed responses over tim”
Next-Generation Influenza Vaccines. (2020, background): “In the presence of the head domain, immune responses directed to the stem are outcompeted by the head-directed response (Ellebedy et al. 2014; Andrews et al. 2015; Tan et al. 2019).”