Microvascular blood flow is altered in patients with sepsis.

By D. De Backer, J. Creteur, J. Preiser, M. Dubois, Jean-Louis Vincent. American Journal of Respiratory and Critical Care Medicine, 2002

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Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. (2007, methodology): “... We selected the sublingual space as the site of imaging because (1) it shares the same embryologic (and therefore anatomic) origin as the splanchnic mucosa, (2) derangements in sublingual perfusion Figur e1 .Th eearl ygoal-directe dtherap yprotoco l(ou radaptation1 5o fth eorigina lprotoco lb yR”
Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock* (2004, methodology): “An investigator, blinded to the patients’ clinical course and the order of the sequences, analyzed the sequences semiquantitatively (4).”
The microcirculation is the motor of sepsis (2005, background): “De Backer and colleagues reported similar microcirculatory abnormalities in septic patients [7].”
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine (2014, result): “cular alterations, similar to those reported in experimental conditions, have been observed in patients with septic [145], cardiogenic [146], and hemorrhagic [147] shock.”