Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock*

By Y. Sakr, M. Dubois, D. De Backer, J. Creteur, Jean-Louis Vincent. Critical Care Medicine, 2004

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The microcirculation is the motor of sepsis (2005, background): “Studies by de Backer and colleagues [7], Spronk and colleagues [10], and Sakr and colleagues [2] on the sublingual microcirculation using OPS imaging in septic patients have directly associated the degree of microcirculatory distress with disease severity and response to therapy.”
Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. (2007, background): “Inclusion criteria were (1) 18 years of age or older; (2) confirmed or suspected infection plus 2 or more signs of the systemic inflammatory response syndrome (definition of sepsis by American College of Chest Physicians/Society of Critical Care Medicine criteria)20; ( 3 ) 1 or both of the following”