Hfq and its constellation of RNA
By Jörg Vogel, B. Luisi. Nature Reviews Microbiology, 2011
1,018 citations recorded by the source corpus.
Hfq is an RNA-binding protein that is common to diverse bacterial lineages and has key roles in the control of gene expression. By facilitating the pairing of small RNAs with their target mRNAs, Hfq affects the translation and turnover rates of specific transcripts and contributes to complex post-transcriptional networks. These functions of Hfq can be attributed to its ring-like oligomeric architecture, which presents two non-equivalent binding surfaces that are capable of multiple interactions with RNA molecules. Distant homologues of Hfq occur in archaea and eukaryotes, reflecting an ancient origin for the protein family and hinting at shared functions. In this Review, we describe the salient structural and functional features of Hfq and discuss possible mechanisms by which this protein can promote RNA interactions to catalyse specific and rapid regulatory responses in vivo.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/c83067a837feb641c08009418927dc80efa1d7a8
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Citations in the corpus
- Extracting intracellular diffusive states and transition rates from single-molecule tracking data (2013, methodology): “To test the method on a biological system, we studied the RNA helper protein Hfq 11,12 (UniProtKB: P0A6X3), which mediates posttranscriptional gene regulation by facilitat ing interactions between mRNA and noncoding small RNA (sRNA).”
- Regulation by Small RNAs in Bacteria: Expanding Frontiers (2011, neutral): “Cellular copy numbers are unknown for most sRNAs and target mRNAs, and even the level of Hfq remains controversial in E. coli (400 versus 10,000 copies) and has not been determined in other organisms (reviewed in Vogel and Luisi, 2011).”