Regulation by Small RNAs in Bacteria: Expanding Frontiers

By G. Storz, Jörg Vogel, K. Wassarman. Molecules and Cells, 2011

1,157 citations recorded by the source corpus.

Research on the discovery and characterization of small, regulatory RNAs in bacteria has exploded in recent years. These sRNAs act by base pairing with target mRNAs with which they share limited or extended complementarity, or by modulating protein activity, in some cases by mimicking other nucleic acids. Mechanistic insights into how sRNAs bind mRNAs and proteins, how they compete with each other, and how they interface with ribonucleases are active areas of discovery. Current work also has begun to illuminate how sRNAs modulate expression of distinct regulons and key transcription factors, thus integrating sRNA activity into extensive regulatory networks. In addition, the application of RNA deep sequencing has led to reports of hundreds of additional sRNA candidates in a wide swath of bacterial species. Most importantly, recent studies have served to clarify the abundance of remaining questions about how, when and why sRNA-mediated regulation is of such importance to bacterial lifestyles.

Subfields: Ecology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/436b34001be677657fa614f605533fc2b11f8273

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Citations in the corpus

Genome-wide identification of novel small RNAs in Pseudomonas aeruginosa (2013, background): “Wiley Online Library; 2010;34(5):866–82.”
Global mapping of transcription start sites and promoter motifs in the symbiotic α-proteobacterium Sinorhizobium meliloti 1021 (2013, neutral): “Prokaryotic asRNAs are generally short transcripts of approximately 100 to 300 nt [2].”
CopraRNA and IntaRNA: predicting small RNA targets, networks and interaction domains (2014, background): “In recent years, bacterial small RNAs (sRNAs) have proven to be potent, versatile and important regulators of prokaryotic gene expression (1,2).”
Bacterial quorum sensing: its role in virulence and possibilities for its control. (2012, background): “Small regulatory RNAs (sRNAs) in bacteria act by basepairing with mRNA targets to repress or activate gene expression (reviewed in Gottesman 2004; Papenfort and Vogel 2010; Storz et al. 2011).”
Global Mapping of Small RNA-Target Interactions in Bacteria (2016, background): “Most known sRNAs exert their regulatory function by base-pairing with their target RNAs, usually affecting the target translation, stability, and/or processing (Storz et al., 2011; Wagner and Romby, 2015).”