Metabolite profiling: from diagnostics to systems biology

By Alisdair R. Fernie, R. Trethewey, A. Krotzky, Lothar Willmitzer. Nature reviews. Molecular cell biology, 2004

808 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c7e396c2e94f70cd66cd726a1e9a5c4dd4516e12

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Citations in the corpus

The use of metabolomics to dissect plant responses to abiotic stresses (2012, methodology): “The crucial advantage of this technology is that it has long been used for metabolite profiling, and thus there are stable protocols for machine setup and maintenance, and chromatogram evaluation and interpretation [9–11].”
GC–MS libraries for the rapid identification of metabolites in complex biological samples (2005, background): “[13,24], which was already apparent in earliest metabolomics applications in clinical diagnostics [25], but it will also aid laboratories entering the field of metabolomics.”
The Herbicide Saflufenacil (Kixor™) is a New Inhibitor of Protoporphyrinogen IX Oxidase Activity (2010, methodology): “In addition, metabolite profiling was carried out in treated duckweed plants in order to diagnose the herbicidal mode of action and involved metabolic steps (Fernie et al. 2004; Sauter et al. 1991).”
Ecological metabolomics: overview of current developments and future challenges (2011, background): “Typical non-plant eukaryotic organisms are estimated to contain from 4,000 to 20,000 metabolites (Fernie et al. 2004), and the plant kingdom produces 100,000–200,000 different metabolites (Fiehn et al. 2001), although the actual number present in any individual plant species is still unknown.”
Systems medicine: the future of medical genomics and healthcare (2009, neutral): “and environment factors [70-72].”
Comparative Metabolome Analysis of the Salt Response in Breeding Cultivars of Rice (2007, background): “At the onset of the post-genomic era the concept of metabolome analysis has sparked a new interest in plant metabolism (Trethewey et al. 1999, Fiehn et al. 2000, Fiehn 2002, Sumner et al. 2003, Bino et al. 2004, Fernie et al. 2004, Jenkins et al. 2004, 285 and Salt Tolerant Crops, 285–315.”
GMD@CSB.DB: the Golm Metabolome Database (2005, background): “The recent mining and exploitation of data by multiparallel ‘omics’ technologies open up the possibility to gain comprehensive insight into the understanding of biological systems (Kitano, 2002; Oltvai and Barabási, 2002; Fernie et al., 2004).”
Halophyte Improvement for a Salinized World (2010, background): “…of plant metabolomics, such as the fundamental principles and the state-of-the-art technical aspects of metabolomics (Sumner et al., 2003; Fernie et al., 2004; Saito et al., 2006; Ward et al., 2007; Allwood et al., 2008), the environmental standards for biological samples (Morrison et…”
RIKEN tandem mass spectral database (ReSpect) for phytochemicals: a plant-specific MS/MS-based data resource and database. (2012, background): “Metabolomics is an ‘‘omics’’ approach to the investigation of metabolites present in biological samples (Fernie et al., 2004; Weckwerth, 2003).”
Computational mass spectrometry for small molecules (2013, background): “For a general introduction to metabolomics and metabolomic proﬁling see [2,3,38]; for recent work in the ﬁeld see [39].”
Rewiring of the Fruit Metabolome in Tomato Breeding. (2018, background): “While metabolome coverage is not as comprehensive (Fernie et al., 2004), advances in highthroughput metabolic profiling have rendered metabolomics an important tool for both fundamental and applied research (Saito and Matsuda, 2010).”