mTOR at the nexus of nutrition, growth, ageing and disease
By Grace Y. Liu, David M. Sabatini. Nature reviews. Molecular cell biology, 2020
2,308 citations recorded by the source corpus.
The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR signalling landscape has revealed that mTOR controls biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Given the pathway’s central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing. In this Review, we highlight recent advances in our understanding of the complex regulation of the mTOR pathway and discuss its function in the context of physiology, human disease and pharmacological intervention. The mTOR pathway integrates diverse environmental cues to control biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing, and is thus a promising target for pharmacological intervention.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/c7db290a042cd4c9f9e22e36ea79e757dfa07a77
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In Molecular Biology
Citations in the corpus
- Autophagy in inflammation, infection, and immunometabolism (2021, background): “AMPK and mTOR work as the yin and the yang of cellular metabolism, and act in opposing ways to control both autophagy (Herzig and Shaw, 2018; Liu and Sabatini, 2020) and immunometabolism, profoundly affecting immune cell function (O’Neill and Hardie, 2013; O’Neill et al.”