Diet–microbiota interactions as moderators of human metabolism

By Justin L. Sonnenburg, F. Bäckhed. Nature, 2016

1,965 citations recorded by the source corpus.

It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light through a powerful combination of translation-focused animal models and studies in humans. A body of knowledge is accumulating that points to the gut microbiota as a mediator of dietary impact on the host metabolic status. Efforts are focusing on the establishment of causal relationships in people and the prospect of therapeutic interventions such as personalized nutrition.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/c7daa43927fc48c73d06c57e9cb1721793d16a70

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Citations in the corpus

Dietary fiber and prebiotics and the gastrointestinal microbiota (2017, background): “Increasingly, diet is recognized as a key environmental factor that mediates the composition and metabolic function of the gastrointestinal microbiota.(8) Indeed, consumption of specific dietary ingredients, such as fiber and prebiotics, is an avenue by which the microbiota can be modulated.”
Gut Microbiome: Profound Implications for Diet and Disease (2019, background): “Clear links are emerging between the microbiome and its effects on host metabolism, with profound implications for human health given the rise of obesity and metabolic syndrome in Western society [83].”
Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population (2017, background): “are believed to be an important causal factor in development of obesity [13].”
Pathophysiology of Atherosclerosis (2022, background): “During the last few years, we are witnessing an increased burden of atherosclerotic disease that contributes to CVD risk, which is becoming a global epidemic.”
Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019, background): “With the gut microbiota able to fluctuate in as short a time span as an hour [17], poses the question of whether hunger related to delayed feeding could potentially manipulate the composition of the gut microbiota.”
The Effects of Vegetarian and Vegan Diets on Gut Microbiota (2019, background): “Dietary composition appears to have long-term and acute effects on the gut microbiota ecosystem (19, 20).”
Dietary lipids, gut microbiota and lipid metabolism (2019, background): “The gut microbiota regulates many metabolic processes in the host including energy homeostasis, glucose metabolism and lipid metabolism [1].”
Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis (2022, background): “A high microbiota diversity is associated with digestion of many types of complex carbohydrates with production of several SCFAs and additional gut microbiota diversity [26].”