Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.

By A. Ferrando, D. Neuberg, J. Staunton, M. Loh, C. Huard, S. Raimondi, F. Behm, Ching-Hon Pui, J. Downing, D. Gilliland and 3 more. Cancer Cell, 2002

1,143 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c7bb60ebdc1bf1c63103cf3d20f4b2184e34c0a8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. William E. Evans
2. Ching-Hon Pui
3. Mary V. Relling
4. Snorri Thorgeirsson
5. Magnus Ingelman-Sundberg

In Molecular Biology

1. Limsoon Wong
2. Ching-Hon Pui
3. Qi Duan
4. Andrew F. Laine
5. Dean W. Felsher
6. John K. Gohagan
7. Huiqing Liu
8. Armen R. Kherlopian

Citations in the corpus

• A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells (2006, result): “Previous studies in diffuse large B-cell lymphoma and T-cell acute lymphoblastic leukemia indicated that the cellular origins of a tumor largely dictate the clinical outcome of patient”
• Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. (2002, background): “The average intensity difference (AID) values were normalized strong et al., 2001; Ferrando et al., 2002).”
• EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes (2012, background): “Conversely, a significant number of T-ALL molecular abnormalities are associated with a specific T-cell maturation arrest (164) or gene expression profile (153, 165, 166).”
• A review of imaging techniques for systems biology (2008, methodology): “Major efforts are underway to apply systems biology methods to oncology [19, 20 ].”
• Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia (2007, background): “We have shown before that aberrant expression of transcription factor oncogenes involved in the pathogenesis of T-cell tumors, such as TAL1 , TLX1 , TLX3 , LYL1 , LMO1 and LMO2 , define distinct molecular, biological and clinical groups of T-ALL”
• c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. (2006, background): “Importance of Notch/myc interaction in normal and neoplastic pre-T cells T-ALLs appear to resemble various stages of pre-T-cell development (Ferrando et al. 2002; Asnafi et al. 2003), during which Notch signaling outcomes may differ dramatically.”