Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

By A. Bell, G. Felsenfeld. Nature, 2000

1,783 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/c7ac949bec01d22fe97801babcf2d8b059f6685e

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In Genetics

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In Pediatrics, Perinatology and Child Health

Citations in the corpus

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus (2000, result): “These studies support the hypothesis that Igf2 imprinting requires a chromatin boundary element that lies between the gene and enhancers 3′ of the IC”
Widespread plasticity in CTCF occupancy linked to DNA methylation (2012, background): “…variable CTCF occupancy has been linked with DNA methylation in vivo (Kanduri et al. 2000; Pant et al. 2003), and in vitro studies suggest that methylation may hinder CTCF binding at certain sequence elements (Bell and Felsenfeld 2000; Hark et al. 2000; Filippova et al. 2001; Renda et al. 2007).”
YY1 Is a Structural Regulator of Enhancer-Promoter Loops (2017, neutral): “methylated DNA sequences (Bell and Felsenfeld, 2000; Yin et al., 2017), are ubiquitously expressed (Figure 1C) (Mele et al.”
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma (2001, background): “Such enhancer-related methylation events have been described for the imprinting of H19 and Igf2 gene”
Genomic imprinting: the emergence of an epigenetic paradigm (2011, background): “The element functions through interaction with the zinc-finger protein CCCTC-binding factor (CTCF), which binds DNA in a methylation-sensitive manner and preferentially targets the unmethylated maternal chromosom”
A decade of exploring the cancer epigenome — biological and translational implications (2011, background): “In this process, a gain of CpG methylation (hypermethylation not hypomethylation) in the insulator region immediately upstream of the imprinted H19 gene on chromosome 11 is associated with loss of CTCF binding to the regio”
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. (2008, background): “The insulator function of CTCF has also been implicated in imprinting at the Igf2/H19 locus (Bell and Felsenfeld 2000; Hark et al. 2000; Kanduri et al. 2000; Fedoriw et al. 2004).”