Epistasis: too often neglected in complex trait studies?

By Ö. Carlborg, C. Haley. Nature reviews genetics, 2004

974 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c774293d4c49e99a7920d8bd46ffc250d9a23132

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In Genetics

Citations in the corpus

The mystery of missing heritability: Genetic interactions create phantom heritability (2012, background): “Genetic studies in model organisms have long identified specific instances of interacting genes (17).”
Inaugural Article: Epistasis dominates the genetic architecture of Drosophila quantitative traits (2012, neutral): “Chill coma recovery 137 27 Starvation resistance 1,247,469 (267) 91,947 (9)”
QTL mapping for yield and yield contributing traits in two mapping populations of bread wheat (2007, background): “A dissection of these interactions is needed to better understand the genetic control of a trait (Holland 2001; Mackay 2001; Carlborg and Haley 2004; Erickson 2005).”
Genomic Selection for Crop Improvement (2017, neutral): “There is current debate, at both theoretical and empirical levels, of the likely importance of epistasis in the architecture of quantitative traits (Carlborg and Haley, 2004; Hill et al., 2008; Holland, 2007; Mackay, 2008).”
Linkage disequilibrium and association studies in higher plants: Present status and future prospects (2005, methodology): “In recent years, methods have been developed and utilized in plants to find such QTLs, which do not have their main effect, but are involved in epistasis (Yu et al., 1997; Wang et al., 1999; Xing et al., 2002; Kulwal et al., 2004; for a recent review, see Carlborg and Haley, 2004).”
The genomics of local adaptation in trees: are we out of the woods yet? (2017, background): “Indeed, it is often argued that nonadditive gene action is too often neglected in studies of complex traits (e.g., Carlborg & Haley 2004), possibly due to the large sample sizes required to detect significant interactions, and lack of statistical power incurred due to multiple hypothesis testing…”
Mapping the genetic architecture of complex traits in experimental populations (2007, background): “The term epistasis was primarily coined to describe the distortions of Mendelian segregation ratios that were due to one gene masking the effects of another in classical genetic studies on qualitative variations such as coat color (i.e. the albino allele of tyrosinase masks the phenotypes of other l”