Hydroxylation of HIF-1: oxygen sensing at the molecular level.

By G. Semenza. Physiology, 2004

937 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/c7526355ac1f22e25e25a6cd8a3ca7673ef20ef3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. G. Semenza
2. C. V. Dang
3. Jung-whan Kim
4. Richard J. Johnson
5. D. Liao
6. Ralph J. Deberardinis
7. M. V. Vander Heiden
8. Craig B. Thompson

In Cell Biology

1. G. Semenza
2. Richard J. Johnson
3. D. Liao
4. C. V. Dang

In Physiology

1. Richard J. Johnson
2. D. Liao
3. C. V. Dang
4. Jung-whan Kim
5. G. Semenza

Citations in the corpus

• Hypoxia: A key regulator of angiogenesis in cancer (2007, background): “tumor suppressor protein von Hippel-Lindau (VHL) to the N-terminal transactivation domain (TAD-N) of HIF-1α [15].”
• HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. (2006, background): “HIF-1 is a heterodimeric transcription factor, consisting of HIF1a and HIF-1b subunits, which functions as a master regulator of oxygen homeostasis in all metazoan species (Schofield and Ratcliffe, 2004; Semenza, 2004).”