The Interleukin-8 Pathway in Cancer

By D. Waugh, Catherine H. Wilson. Clinical Cancer Research, 2008

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Muscles and their myokines (2011, background): “Accordingly, IL-8 expression correlates with the angiogenesis, tumourigenicity and metastasis of tumours in numerous xenograft and orthotopic in vivo models (Waugh and Wilson, 2008).”
Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy (2014, result): “The elevations in CXCL8 were higher than that for CXCL1, consistent with a substantial literature implicating CXCL8 in various aspects of tumor growth (37).”
Tumor self-seeding by circulating cancer cells (2009, background): “IL-6 and IL-8 have been implicated in several tumorigenic processes including cancer cell chemoattraction (Arihiro et al., 2000; Wang et al., 1990; Waugh and Wilson, 2008).”
Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases (2017, neutral): “Activation of FAK and Src by CXCL8 signaling resulted in increased cellular proliferation and motility [51].”