Faculty Opinions recommendation of Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.

By M. Cybulsky, J. Jongstra-Bilen. 2013

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Macrophage plasticity, polarization, and function in health and disease (2018, background): “This fact that a number of tissue-resident macrophages are also largely unaffected in patients, which suffering from monocytopenia, is a further document of this assumption (Hashimoto et al., 2013).”
Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches (2019, methodology): “By contrast, and as expected (19),WT Ly6C andLy6Cmonocytes represented>70 and >90% of blood circulating monocytes in Ccr2 mice, respectively (fig.”
Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment (2014, background): “of macrophages derived from transplanted adult bone marrow (BM) that replace endogenous embryo-derived tissue-resident macrophages upon lethal irradiation (Ginhoux et al., 2010; Hashimoto et al., 2013; Schulz et al., 2012; Virolainen, 1968; Yona et al., 2013) (Figure 6A).”
The Metabolic Signature of Macrophage Responses (2019, background): “Interestingly, embryo-derived macrophages retain selfrenewal potential, whereas monocyte-derived cells are terminally differentiated (3).”