Chemerin, a Novel Adipokine That Regulates Adipogenesis and Adipocyte Metabolism*
By K. Goralski, Tanya C. McCarthy, Elyisha A. Hanniman, Brian A. Zabel, E. Butcher, S. Parlee, S. Muruganandan, C. Sinal. Journal of Biological Chemistry, 2007
864 citations recorded by the source corpus.
Obesity is an alarming primary health problem and is an independent risk factor for type II diabetes, cardiovascular diseases, and hypertension. Although the pathologic mechanisms linking obesity with these co-morbidities are most likely multifactorial, increasing evidence indicates that altered secretion of adipose-derived signaling molecules (adipokines; e.g. adiponectin, leptin, and tumor necrosis factor α) and local inflammatory responses are contributing factors. Chemerin (RARRES2 or TIG2) is a recently discovered chemoattractant protein that serves as a ligand for the G protein-coupled receptor CMKLR1 (ChemR23 or DEZ) and has a role in adaptive and innate immunity. Here we show an unexpected, high level expression of chemerin and its cognate receptor CMKLR1 in mouse and human adipocytes. Cultured 3T3-L1 adipocytes secrete chemerin protein, which triggers CMKLR1 signaling in adipocytes and other cell types and stimulates chemotaxis of CMKLR1-expressing cells. Adenoviral small hairpin RNA targeted knockdown of chemerin or CMKLR1 expression impairs differentiation of 3T3-L1 cells into adipocytes, reduces the expression of adipocyte genes involved in glucose and lipid homeostasis, and alters metabolic functions in mature adipocytes. We conclude that chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism.
Subfields: Epidemiology, Pharmacology, Physiology
View Paper: https://www.semanticscholar.org/paper/c6e644507ce1fac15b86abddeea1011d515d6bb7
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Citations in the corpus
- Adipokines Mediate Inflammation and Insulin Resistance (2013, background): “In addition chemerin has been shown as an adipokine to regulate adipogenesis and adipocytes metabolism (Goralski et al., 2007) although molecular mechanisms are still controversial (Bondue et al.”
- Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training (2013, neutral): “While two studies published in 2007 (230, 546) suggest that chemerin modulates adipogenesis and that receptors for the adipokine are present in immune cells, little is known regarding the functional role of this adipokine or its true relationship to disease pathology.”