Heparan sulphate proteoglycans fine-tune mammalian physiology

By J. R. Bishop, Manuela Schuksz, J. Esko. Nature, 2007

1,588 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/06224cd1d420e9566157bbfca0750bf3ef64868a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. A. Varki
2. Ding Xu
3. Alexandra Naba
4. S. Sarrazin
5. William C. Lamanna
6. R. Hynes
7. J. Esko
8. Peter Friedl

In Molecular Biology

1. A. Varki
2. Ding Xu
3. S. Sarrazin
4. William C. Lamanna
5. Alexandra Naba
6. R. Hynes
7. J. Esko
8. R. Wanders

Citations in the corpus

• Demystifying Heparan Sulfate–Protein Interactions (2014, background): “Our knowledge about the physiological functions of HS has exploded during the past 30 years, largely because of the identification and characterization of numerous HSBPs (5).”
• Biological roles of glycans (2016, background): “As an example, null alleles preventing the synthesis of the core glycosaminoglycan backbone of heparan sulfate causes embryonic lethality (421) (422) , but the prevention of proper sulfation of this backbone can give living mice with specific defects (422) (423) (424) (425) (426) (427) .”
• Syndecan–syntenin–ALIX regulates the biogenesis of exosomes (2012, background): “Note that truncated forms of Alix containing the V domain interact with the two parts of the N-Ter domain of syntenin that contain LYPXL motifs, (1-30) and (31-60), and that mutation of the three LYPXL motifs (YP to AA) abolishes the interaction.”
• Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome. (2017, background): “HSPGs are a major component of the extracellular matrix (ECM) in all organs in the human body and are involved in numerous physiological processes.(12) Notably, there are three subfamilies of HSPGs:membrane-spanningproteoglycans, glycophosphatidylinositol-anchored proteoglycans, and secreted ECM pro”
• Inflammation, endothelium, and coagulation in sepsis (2008, background): “Direct binding of bacteria to HSPGs on alveolar epithelium has been described; however, this phenomenon has not been reported for HSPGs on endothelium, nor has this finding been substantiated in vivo [73].”
• The Structure of Glycosaminoglycans and their Interactions with Proteins (2008, background): “HSPGs are the major component of ECM (extracellular matrix) in mammals (75).”
• Overview of the matrisome--an inventory of extracellular matrix constituents and functions. (2012, background): “Further details of structure and functions of various heparan sulfate 4 Cite this article as Cold Spring Harb Perspect Biol 2012;4:a004903 proteoglycans are discussed by Bishop et al. (2007) and Sarrazin et al. (2011).”
• Heparan sulfate proteoglycans. (2011, methodology): “(Adapted from Bishop et al. 2007; reprinted with permission from Nature Publishing Group # 2007.)”