Faculty Opinions recommendation of Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current.

By B. Adams. 2005

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PIP2 is a necessary cofactor for ion channel function: how and why? (2008, background): “The suppression by Gq/11-coupled receptors (31, 81) or by inducible translocation of PIP2 5-phosphatase (82) takes only 10 s, which is comparable to the estimated time course for the depletion of membrane PIP2 by these maneuvers.”
SYMPOSIUM REVIEW: Phosphoinositides: lipid regulators of membrane proteins (2010, unknown): “In an expression system, we showed that PIP2 is depleted by M1 receptor activation (Horowitz et al. 2005), and current is suppressed (Fig.”
Local PIP2 signals: when, where, and how? (2007, background): “From work with cell cultures with constitutively overexpressed PLCcoupled receptors, we know that almost all of the PIP2 that we measure can be cleaved within seconds upon activating receptors [34].”