Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium.
By Ovijit Chaudhuri, Sandeep T. Koshy, Cristiana Branco da Cunha, Jae-Won Shin, Catia Verbeke, K. Allison, David J. Mooney. Nature Materials, 2014
776 citations recorded by the source corpus.
Subfields: Cell Biology, Immunology and Allergy, Oncology
View Paper: https://www.semanticscholar.org/paper/c650484271c1e751b6aeaebc4bfd4b6b2869d318
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Citations in the corpus
- Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression (2015, background): “have demonstrated that in mammary epithelium, mechanical signals induced by ECM stiffness are mediated by the b4 integrin-Rac1-PI3K pathway, and malignant phenotypes of cells are induced when ECM stiffness is increased.(20) Together, these studies demonstrate that cells respond to ECM stiffness by r”
- Extracellular matrix (ECM) stiffness and degradation as cancer drivers (2018, background): “Extensive remodeling of ECM during cancer progression causes alterations in its density and composition.(6)”