Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs.

By J. Cyster, Susan R. Schwab. Annual Review of Immunology, 2012

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How researchers see this paper

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Tissue-Resident Memory T Cells (2014, background): “S1PR1 mediates T cell egress in lymph nodes by inducing chemotaxis to sphingosine-1-phosphate (S1P) present within efferent lymph (Cyster and Schwab, 2012).”
Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “The regulation of effector lymphocyte egress from the LN is similar to what we have described for naive T cells above and has recently been thoroughly reviewed (171).”
GERMINAL CENTER B CELL DYNAMICS (2016, positive): “Interestingly, when GC B cells are made resistant to apoptosis by expression of a Bcl2 transgene, ablation of the FDC network itself causes GC B cells to disperse, suggesting that FDCs may help maintain low concentrations of S1P, and possibly of a putative P2YR8 ligand, in the follicle center (Muppi”
Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition (2013, background): “S1PR5 is essential for NK cell migration; NK cells accumulate in the bone marrow and lymph nodes in its absence (133, 134).”