Therapeutic interventions after spinal cord injury

By S. Thuret, L. Moon, Fred H. Gage. Nature Reviews Neuroscience, 2006

1,071 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Genetics, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/c633a29cdd0c50c98ec409fcdaee139c28808d1e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Sofroniew
2. Y. Ao
3. B. Song
4. Jingwei Qi
5. J. Herrmann
6. Ali Khademhosseini
7. J. Frisén
8. M. Pekny

In Pathology and Forensic Medicine

1. M. Sofroniew
2. C. Oyinbo

Citations in the corpus

• Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury (2008, background): “but little is known about which neural systems would be most effective to target with such intervention”
• The Influence of Hydrogel Modulus on the Proliferation and Differentiation of Encapsulated Neural Stem Cells (2009, positive): “NSCs have the ability to differentiate into the three major neural lineages – neurons, oligodendrocytes, and astrocytes [17,18] – and are thus of interest for a range of neuroregenerative applications [2,17,19-22].”
• Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells (2008, background): “The beneficial effects appear to be mediated by several mechanisms, including replacement of lost cells, secretion of neurotrophic factors, and probably most importantly, the generation of oligodendrocytes that remyelinate spared axons in the vicinity of a lesion [1,2].”
• Self-Assembling Nanofibers Inhibit Glial Scar Formation and Promote Axon Elongation after Spinal Cord Injury (2008, background): “Although adult CNS neurons have the intrinsic capacity to regenerate axons after injury (Richardson et al., 1980), axon elongation and functional recovery after SCI is limited because of an unfavorable extracellular milieu (Silver and Miller, 2004; Thuret et al., 2006).”
• Engineering microscale topographies to control the cell–substrate interface (2012, background): “In SCI, the injured axons encounter an inhibitory environment for growth that restricts their ability to make synapses with previously connected cells [206].”
• Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade. (2011, background): “The therapeutic strategies were generally: to protect neurons from secondary cell death; to promote axonal growth; and to enhance conduction (Thuret et al. 2006).”