Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade.

By C. Oyinbo. Acta Neurobiologiae Experimentalis, 2011

735 citations recorded by the source corpus.

The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary mechanisms of injury. Though both mechanisms are involved in the neurological dysfunction in SCI most research however has focused on understanding the pathophysiology of the secondary damage and reducing the amount of delayed cell loss following SCI. Research has revealed extensive therapeutic windows in secondary injury mechanisms that could be manipulated by appropriate exogenous interventions. In contrast, primary injury to the cord happens unexpectedly, and it is associated with inevitable delays; ranging from several hours to days before care intervention is administered. Therefore, apart from achieving patient's stabilization, the therapeutic window in the primary phase of injury is essentially obliterated, and consequently inaccessible for specialized. Coupled to this, the exacerbating effect of secondary injury mechanisms has generally commenced before the specialist intervention. Hence, knowledge of secondary injury mechanisms and their intricacies are invaluable requisite for any tailored therapeutic strategy in the persistent search for a cure of SCI. There are about 25 well-established secondary injury mechanisms in SCI, and are found in bits or clusters in literature. A vast number of these articles are not open access. Besides, articles with a comprehensive catalog of these mechanisms are not readily available. This article has cataloged over twenty five identified secondary mechanisms of injury in the spinal cord in an open access portal, and is particularly versatile for starters in spinal cord injury research.

Subfields: Cellular and Molecular Neuroscience, Genetics, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/81312216495186e1d35f6958c59587714efca557

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Citations in the corpus

• Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms (2019, background): “Microglia are resident immune cells of the CNS that originate from yolk sac during the embryonic period (221).”
• Spinal cord injury: molecular mechanisms and therapeutic interventions (2023, background): “The pathophysiological mechanisms driving the secondary injury after SCI are complex and SCI is a heterogeneous condition.(27,33,325) Single treatment may only affect a small portion of mechanisms, whereas combinatorial treatment targeting multiple mechanisms is potentially a better therapeutic sele”