Modulating Hox gene functions during animal body patterning

By Joseph C. Pearson, Derek Lemons, W. McGinnis. 2005

917 citations recorded by the source corpus.

Subfields: Biomaterials, Genetics, Molecular Biology

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In Genetics

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Citations in the corpus

Long Noncoding RNAs: Past, Present, and Future (2013, background): “The Hox genes encode homeodomain TFs that are crucial for anterior–posterior pattern formation in all bilaterian metazoans (Pearson et al. 2005).”
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. (2006, background): “The vertebrate homeotic HOX genes are located in four distinct clusters (A, B, C, D) that are organized into 13 homology (or paralog) groups (Pearson et al. 2005).”
Homeodomain proteins: an update (2015, background): “They play crucial roles in patterning, in particular the Hox genes (Capellini et al. 2011; Kmita and Duboule 2003; Maeda and Karch 2015; Pearson et al. 2005; Rezsohazy et al. 2015; Seifert et al. 2015; Zakany and Duboule 2007).”
The neuronal microRNA system (2006, background): “Homeobox (Hox) genes function in patterning the anterior–posterior axis of the CNS, and miRNA genes in the Hox gene clusters provide control over development (for a review, see Ref”
Functional specificity of a Hox protein mediated by the recognition of minor groove structure. (2007, neutral): “To execute their functions, Hox proteins regulate many types of target genes, some of which are specific for a particular Hox paralog ( Pearson et al., 2005 ).”
Differential analysis of gene regulation at transcript resolution with RNA-seq (2012, methodology): “We use Cuffdiff 2 to assess the response to knockdown of HOXA1 , a member of a highly conserved family of transcription factors that establish body plan organization during development 26 .”