High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

By Carolyn I. Rodriguez, F. Buchholz, J. Galloway, Reynaldo Sequerra, J. Kasper, Ramsés Ayala, A. Stewart, S. Dymecki. Nature Genetics, 2000

1,224 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c5f2477bf148384b61168a30ca69c8474b28b5d4

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Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. (2002, methodology): “Although some success has been achieved using the Cre-LoxP genetic system (Herrera, 2000; Kimmel et al., 2000; Kisanuki et al., 2001; Rodriguez et al., 2000), one drawback of the system in its simplest form is that cells are marked from the time when the promoter driving Cre expression is first…”
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. (2006, background): “The Frt-flanked PGK-neo cassette was excised by crosses to Actin-Flpe mice (Rodriguez et al. 2000), generating the Smad4Lox allele.”
Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development (2011, methodology): “Tg.pCAG–Flpe (Rodriguez et al., 2000) or Tg.CMV-Cre (Schwenk et al., 1995) transgenic mice were used for ubiquitous expression of Flp or Cre recombinases.”
Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males (2013, methodology): “We bred the F1 progeny of these chimeras to mice expressing Flpe recombinase ubiquitously (Rodrı́guez et al., 2000).”
Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis. (2017, neutral): “2-rosa26 Hitz et al., 2007 N/A Human: HEK293T Clonetech Cat#632180 Experimental Models: Organisms/Strains Mouse:Rosa26_Flpe:WT Rodrı́guez et al., 2000 N/A Mouse:Gpx4fl/fl;Rosa26_CreERT2 Friedmann Angeli et al., 2014 N/A (Continued on next page) e2 Cell 172, 1–14.e1–e11, January 25, 2018 Please cite ”
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver (2010, neutral): “FRT-flanked neo cassettes were removed in vivo by crossing to Flpe deleter mice (34).”