Laboratory routines cause animal stress.

By J. Balcombe, N. Barnard, Chad B. Sandusky. Contemporary topics in laboratory animal science, 2004

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Sources of stress in captivity (2007, background): “For instance, walking into a laboratory housing rhesus macaques while carrying leather gauntlet gloves used for handling animals for aversive procedures is so arousing to the animals that we have used it specifically to induce a stress response in our subjects! Data documenting the effects of routin”
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice (2010, background): “Sampling from an arterial catheter has the advantage of providing vascular access during an experiment without introducing handling stress (Balcombe et al., 2004; Ayala et al., 2006).”
What is it like to be a rat? Rat sensory perception and its implications for experimental design and rat welfare (2008, background): “Drugs and inoculants are often delivered by gavage, a tube inserted via the mouth into the stomach, which can be technically difficult, and causes stress, respiratory distress, and occasionally even death (Balcombe et al., 2004).”