How useful is SBF in predicting in vivo bone bioactivity?

By T. Kokubo, H. Takadama. Biomaterials, 2006

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Bioactive nanoengineered hydrogels for bone tissue engineering: a growth-factor-free approach. (2015, neutral): “stimulated body fluid (SBF), can be used to evaluate the in vitro osteogenic bioactivity of the hydrogel network.(31) When a biomaterial’s surface is submerged in SBF, the formation of apatite-”
Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review (2011, background): “Table 5 shows the ion concentration comparison between SBF and blood plasma adapted from Kokubo and Takadama [107].”
Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis--a review. (2014, background): “In 2003, a refined recipe of conventional SBF was proposed to the Technical Committee ISO/TC150 of the International Organisation for Standardisation as a solution for the in vitro measurement of the apatite-forming ability of implant materials [198].”