A single-molecule study of RNA catalysis and folding.

By X. Zhuang, L. Bartley, H. Babcock, R. Russell, T. Ha, Daniel Herschlag, Steven Chu. Science, 2000

675 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c50db9c6a06f8fa10fcd1d308532062850cf130d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Learning rates and states from biophysical time series: a Bayesian approach to model selection and single-molecule FRET data. (2009, methodology): “, the folding/unfolding rates of a ribozyme) via statistical inference (1, 2, 3, 4, 5, 6, 7, 8, 9).”
A practical guide to single-molecule FRET (2008, background): “, smFRET time trajectories are most commonly acquired by imaging surface immobilized molecules with the aid of total internal reflection (TIR) microscopy that allows high-throughput data samplin”
Analysis of single-molecule FRET trajectories using hidden Markov modeling. (2006, methodology): “Here we present an algorithm that utilizes the time-binned data obtained from the higher throughput wide-field apparatus, where single-molecule data are obtained for hundreds of molecules at the same time using a CCD camera (16, 17) though in fact it could be applied to any time-binned data regardle”
The 'right' size in nanobiotechnology (2003, neutral): “A substantial effort has focused on observations of catalytic activity in enzymes, where at least some of the fluctuations are relatively slo”
Mechanics of biomolecules (2002, background): “…transfer (FRET) between donor and acceptor dye molecules is extremely sensitive to their relative distance (¡10 nm); it has been used for studying the conformational changes during RNA folding (Zhuang et al., 2000), and coexisting conformations of ,bronectin in cell culture (Baneyx et al., 2001).”
A molecular ruler based on plasmon coupling of single gold and silver nanoparticles (2005, background): “dtd" [ ]> Forster Resonance Energy Transfer has served as a molecular ruler that reports conformational changes and intramolecular distances of single biomolecule”