Molecular markers of breast cancer metastasis

By ritta Weigelt' J. van, 't Veer. 2005

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In Vitro Tumor Models: Advantages, Disadvantages, Variables, and Selecting the Right Platform (2016, background): “Metastasis is responsible for more than 90% of cancer-related deaths (Weigelt et al., 2005; Mehlen and Puisieux, 2006); however, many details of the steps in the metastatic cascade remain poorly understood (Wirtz et al., 2011).”
Genetic determinants of cancer metastasis (2007, background): “The risk of metastatic recurrence can sometimes be predicted from certain features of the primary tumour, as in the case of breast cancer, for which tumour size, histological grade , and gene-expression pattern are indicative of the risk of relaps”