Properties of mouse and human IgG receptors and their contribution to disease models.

By P. Bruhns. Blood, 2012

873 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/c48b1b327a52aea504255a9ccaee5a12c9aacd90

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Erin R Green
2. G. T. Nguyen
3. J. Mecsas
4. K. Futosi
5. Szabina Fodor
6. Sonja James
7. H. Chan
8. A. Korman

In Molecular Biology

1. Sonja James
2. H. Chan
3. Erin R Green
4. G. T. Nguyen
5. A. Mócsai
6. M. Cragg
7. J. Mecsas
8. M. Glennie

In Radiology, Nuclear Medicine and Imaging

1. Sonja James
2. H. Chan
3. A. Mócsai
4. M. Cragg
5. M. Glennie
6. K. Cleary

Citations in the corpus

• Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells (2013, background): “been shown to havemarkedly different effects on their biologic activities (28).”
• Diverse novel functions of neutrophils in immunity, inflammation, and beyond (2013, background): “However, deficiency of the NADPH oxidase component Nox2 exacerbated, rather than inhibited disease pathogenesis in lupus-prone mice (Campbell et al., 2012), arguing against the role of NETs in SLE pathogenesis.”
• Antibody distance from the cell membrane regulates antibody effector mechanisms (2017, methodology): “All of the work presented in this article used the hIgG1 isotype (or mIgG2a in vivo as the closest mouse parallel) (10), because this reflects the isotype typically adopted for direct-targeting mAbs in the clinic (23).”
• The Multifaceted Functions of Neutrophils (2013, background): “The pentraxin molecules, a family of secreted PRRs, represent a third major type of opsonin that engages both FcγRs and CRs (87).”
• Neutrophil cell surface receptors and their intracellular signal transduction pathways (2013, background): “Those include the immunoreceptor tyrosine-based inhibitory motif (ITIM) containing FcγRIIB and PIR-B which likely signal through the SHP-1 tyrosine phosphatase [44,45,231], as well as the inhibitory IL-10 receptor [133].”
• Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “Specifically, low-affinity Fcγ receptors (FcγRs) are transmembrane proteins that bind to the Fc portion of IgG and signal through their ITAM (immunoreceptor tyrosine-based activation motif) domains (Bruhns, 2012).”