Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

By S. Ferber, A. Halkin, H. Cohen, I. Ber, Y. Einav, I. Goldberg, I. Barshack, R. Seijffers, J. Kopolovic, N. Kaiser and 1 more. Nature Medicine, 2000

754 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/c47cbac846b006b5d0f0e13a93bf757c448f5eb3

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Citations in the corpus

Insulin production by human embryonic stem cells. (2001, background): “The forward and reverse primer sequences used for determination of human insulin (hIns), IPF1/PDX1, Ngn3, and b-actin were as follows: hIns: 59-GCC TTT GTG AAC CAA CAC CTG-39, 59-GTT GCA GTA GTT CTC CAG CTG-39 (261-bp fragment); IPF1: 59-CCC ATG GAT GAA GTC TAC C-39, 59-GTC CTC CTC CTT TTT CCA C-39 ”
Diabetes associated cell stress and dysfunction: role of mitochondrial and non‐mitochondrial ROS production and activity (2007, background): “…the duodenum and plays a crucial role in pancreatic development and differentiation (Jonsson et al. 1994; Stoffers et al. 1997; Dutta et al. 1998; Ferber et al. 2000; Horb et al. 2003; Miyatsuka et al. 2003; Taniguchi et al. 2003; Cao et al. 2004; Kaneto et al. 2005), and in maintaining normal…”
Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. (2001, background): “Remarkably, the administration to mice of an adenovirusbased vector expressing IDX-1 is sufficient in and by itself to convert a subpopulation of hepatic cells into insulinproducing b-cells that can also restore glucose homeostasis to streptozotocin-induced diabetic mice (54).”