Effects of protein aggregates: An immunologic perspective

By A. Rosenberg. AAPS Journal, 2006

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How researchers see this paper

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Exploiting sequence and stability information for directing nanobody stability engineering (2017, neutral): “Protein aggregation represents another challenge [13,14].”
The immunogenicity of humanized and fully human antibodies (2010, background): “Extrinsic factors such as aggregates and adjuvant-like contaminants are well known to cause issues and have been largely resolved by improvements in manufacturing and formulating practices.(19,20) Extrinsic factors such as the co-medication of the patient, and the patient’s immunological status can ”
Stability of Protein Pharmaceuticals: An Update (2010, neutral): “increased patient morbidity or mortality (300,301).”
Protein aggregation: pathways, induction factors and analysis. (2009, methodology): “The protein aggregates may constitute only a minute fraction of the total protein mass and may be particularly of interest due to their potential role in immunogenicity.(3) Therefore different analytical methods have to be employed in order to detect these minute aggregate fractions as well as to co”
Microneedle technologies for (trans)dermal drug and vaccine delivery. (2012, background): “important risk factors for unwanted protein immunogenicity [145, 151, 152].”