Biodegradable injectable in situ forming drug delivery systems.

By A. Hatefi, B. Amsden. Journal of Controlled Release, 2002

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In situ forming implants - an attractive formulation principle for parenteral depot formulations. (2012, methodology): “In particular the demands for in vivo reaction conditions are quite restricted, such as the need of non-toxic monomers, cross-linking agents and solvents, oxygen rich environments, narrow range of physiologically acceptable temperatures and suitable rates of rapid polymerization [12].”
Stimuli-reponsive polymers and their bioconjugates (2004, background): “[32] Hatefi A, Amsden B.”
Thermoresponsive Polymers for Biomedical Applications (2011, background): “Hatefi and Amsden wrote a detailed review on biodegradable injectable drug delivery systems commenting on the numerous approaches and methods for in situ formation and drug release [35].”
A Review of Curcumin and Its Derivatives as Anticancer Agents (2019, background): “However, a few limitations have arisen in processing clinical applications, including toxicity of unreacted monomers, post-crosslinking shrinkage or fragility of the polymer gels, and rapid discharge of a large amount of the loaded drug during the initial burst release in drug carrier [77].”