Thermoresponsive Polymers for Biomedical Applications
By M. Ward, T. Georgiou. 2011
1,020 citations recorded by the source corpus.
Thermoresponsive polymers are a class of “smart” materials that have the ability to respond to a change in temperature; a property that makes them useful materials in a wide range of applications and consequently attracts much scientific interest. This review focuses mainly on the studies published over the last 10 years on the synthesis and use of thermoresponsive polymers for biomedical applications including drug delivery, tissue engineering and gene delivery. A summary of the main applications is given following the different studies on thermoresponsive polymers which are categorized based on their 3-dimensional structure; hydrogels, interpenetrating networks, micelles, crosslinked micelles, polymersomes, films and particles.
Subfields: Biomaterials, Molecular Medicine, Organic Chemistry
View Paper: https://www.semanticscholar.org/paper/47d0a5c15f1cea0c4acb524cad8cdba8bc8d22bb
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In Biomaterials
In Molecular Medicine
In Organic Chemistry
Citations in the corpus
- pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications (2017, background): “The UCST response in poly(acrylic acid) and poly(acrylamide) is primarily due to the presence of secondary hydrogen bonding which dominates at low temperature and keeps the hydrogel matrix shrunk whereas, with increasing temperature, hydrogen bonds weaken and the hydrophilic ends become exposed lead”
- Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine (2019, background): “This phase change can be exploited for a controlled destabilization of the polymeric micellar structure [33, 34].”
- Advances in Mechanics of Soft Materials: A Review of Large Deformation Behavior of Hydrogels (2015, background): “The potential applications involving hydrogels has grown exponentially to include areas such as biomedical systems, actuators and flow control [Calvert, 2009; Satarkar et al., 2010; Tomatsuet al., 2011; Ward and Georgiou, 2011].”