Probing the relation between force--lifetime--and chemistry in single molecular bonds.

By Evan Evans. Annual Review of Biophysics and Biomolecular Structure, 2001

1,208 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Electrical and Electronic Engineering

View Paper: https://www.semanticscholar.org/paper/c3c728ad03185c4ad9cace33a29d5520e33afe86

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Atomic and Molecular Physics, and Optics

1. Subra Suresh
2. D. Müller
3. Attila Nagy
4. K. Neuman
5. Y. Dufrêne
6. K. Vliet
7. Viola Vogel
8. Gang Bao

In Electrical and Electronic Engineering

1. Viola Vogel
2. Gang Bao
3. George M. Whitesides
4. D. Müller
5. Felix Ritort
6. Subra Suresh
7. M. Sheetz
8. Y. Dufrêne

Citations in the corpus

• Nonequilibrium fluctuations in small systems: From physics to biology (2007, background): “This phenomenology, related to the technique commonly knownn as dynamic force spectroscopy, allows to explore free energy landscapes by varying the pulling speed over several orders of magnitude [130, 131].”
• The nonlinear nature of friction (2004, background): “This coupling is also found in other biological systems, such as protein unfolding, which often follows a stick–slip proces”
• Mechanics of biomolecules (2002, background): “14, the applied forces can lower the energy barrier of molecular unbinding, thus in;uencing the reaction kinetic rates (Evans, 2001).”
• Local force and geometry sensing regulate cell functions (2006, background): “Because of thermal activation, these bonds have modest lifetime”
• Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy (2008, background): “Force spectroscopy in turn spurred the development of, and benefited greatly from, theoretical approaches that permit the extraction of detailed equilibrium thermodynamic parameters from inherently non-equilibrium pulling experiment”
• The biomechanics toolbox: experimental approaches for living cells and biomolecules (2003, methodology): “This BFP method has also been utilized to illustrate the loading-rate dependence of the ligandreceptor unbinding force (Fig. 17b) [ 100 ].”
• Cell and molecular mechanics of biological materials (2003, background): “In certain cases, an applied force can alter the affinity and lifetime of a receptor–ligand pai”
• Atomic force microscopy as a multifunctional molecular toolbox in nanobiotechnology. (2008, background): “Dynamic SMFS (DFS) probes molecular bonds at different force-loads (applied force over time), thereby allowing the approximation of the transition state and kinetic rate of the bond's energy barrie”
• The 'right' size in nanobiotechnology (2003, positive): “Magnetic tweezers have the singular advantage that it is possible to carry out parallel measurements on large numbers of beads, and thus to improve the statistics of measurement”