Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects.

By Ning Li, Minqi Hao, R. Phalen, W. Hinds, A. Nel. Clinical Immunology, 2003

788 citations recorded by the source corpus.

Asthma is a chronic inflammatory disease, which involves a variety of different mediators, including reactive oxygen species. There is growing awareness that particulate pollutants act as adjuvants during allergic sensitization and can also induce acute asthma exacerbations. In this communication we review the role of oxidative stress in asthma, with an emphasis on the pro-oxidative effects of diesel exhaust particles and their chemicals in the respiratory tract. We review the biology of oxidative stress, including protective and injurious effects that explain the impact of particulate matter-induced oxidative stress in asthma.

Subfields: Health, Toxicology and Mutagenesis, Pollution

View Paper: https://www.semanticscholar.org/paper/c3c117ddbe63e3416774dbd26dc90960c4c795d7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Health, Toxicology and Mutagenesis

1. Tian Xia
2. A. Nel
3. Haibin Shi
4. M. Liong
5. Joanne I. Yeh
6. Lutz Mädler
7. B. Gilbert
8. J. Zink

In Pollution

1. Tian Xia
2. A. Nel

Citations in the corpus

• Size-dependent toxicity of metal oxide particles--a comparison between nano- and micrometer size. (2009, background): “The depolarization may be due to structural damage following particle interactions, which has been shown by ultrafine particles that lodge in the mitochondria (Li et al., 2003b).”
• The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. (2008, background): “In addition to the epidemiological evidence, experimental data also suggest an association between particulate pollutants and asthma [1,48].”
• Childhood Incident Asthma and Traffic-Related Air Pollution at Home and School (2010, background): “However, the mixture of pollutants in close proximity to roadways includes transition metals and organic aerosols, which are more plausible causes of asthma than NO2 (Li et al. 2003).”
• Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties (2008, positive): “tivating pro-inflammatory signaling pathways such as the Jun kinase (JNK) and NF- B cascades.(11,12) While ZnO particles could effectively induce JNK activation in RAW 264.”
• Traffic, Susceptibility, and Childhood Asthma (2006, background): “A causal relationship between asthma and traffic-related exposures is biologically plausible, because ambient particulate matter and other oxidant pollutants have been shown to elicit responses relevant to the pathogenesis of asthma (Li et al. 2003).”
• Health effects of air pollution. (2004, background): “These enzymes (eg, heme oxygenase 1 and glutathione-S-transferase) exert cytoprotective, antioxidant, and detoxification effects.(16) If this layer of protection fails, further escalation of oxidative stress (tier 2) leads to mitogen-activated protein kinase/ nuclear factor kB activation and proinfl”