Gene–environment interactions in psychiatry: joining forces with neuroscience

By Avshalom Caspi, Terrie E. Moffitt. Nature Reviews Neuroscience, 2006

1,306 citations recorded by the source corpus.

Subfields: Experimental and Cognitive Psychology, Genetics, Health, Toxicology and Mutagenesis

View Paper: https://www.semanticscholar.org/paper/025f3e844f45d75286632f2bc6408b2d8195c1a5

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In Experimental and Cognitive Psychology

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Citations in the corpus

Preventing Mental, Emotional, and Behavioral Disorders Among Young People: Progress and Possibilities (2009, background): “Most complex behaviors and the most common forms of MEB disorders are likely to arise from a combination of multiple interacting genetic and environmental influences (Caspi and Moffitt, 2006; Rutter, Moffitt, and Caspi, 2006).”
Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits (2010, positive): “Complementary experimental and observational research designs are integral to testing not only the 5-HTT stress-sensitivity hypothesis, but all GxE hypotheses (4, 5).”
The Ecology of Human Development: Evolving Models for Cultural Psychology (2010, positive): “Major conceptual advances of this theory are its specification of ecology, its concrete linkage of conditions with developmental processes, and its formulation of how factors at multiple levels of analysis would inform those conditions and processes.”
Linking Molecules to Mood: New Insight Into the Biology of Depression (2010, positive): “Biological theories of depression’s etiology have traditionally focused on the interplay between genetic risks and environmental/social hazards, with gene x environment interactions invoked to explain how relatively weak genetic vulnerabilities combined with the right environmental triggers may lead”
Computational psychiatry as a bridge from neuroscience to clinical applications (2016, background): “Mappings between health and biology also vary with external circumstances 5 .”
Differential Susceptibility to Environmental Influences (2013, background): “Pertinent to this idea are findings of Caspi and Moffitt (2006) indicating that different genes differentially moderated the effect of child maltreatment on antisocial behavior (MAO-A) and on depression (5HTT).”
Beyond diathesis stress: differential susceptibility to environmental influences. (2009, background): “The specificity of the differential-susceptibility effect is demonstrated if the model is not replicated when other susceptibility factors (i.e., moderators) and outcomes are used (Caspi & Moffitt, 2006; Rutter , 2006).”
Research review: the neurobiology and genetics of maltreatment and adversity. (2010, background): “There is a burgeoning interest in understanding how early adverse experiences impact on the developing brain (e.g., Caspi & Moffitt, 2006; Lupien, McEwen, Gunnar, & Heim, 2009; Teicher et al., 2003).”
Culture–gene coevolution of individualism–collectivism and the serotonin transporter gene (2009, background): “The importance of considering GxE interactions in understanding the aetiology of complex psychiatric disorders has become more widely acknowledged (Caspi & Moffitt 2006; Canli & Lesch 2007; Munafo et al. 2009), yet the association between specific cultural and genetic factors underlying affective…”
Public Health Significance of Neuroticism (2009, result): “In addition, the results of a number of cognate studies of non-human animals are consistent with the hypothesis that variants of the serotonin transporter gene interact with stress levels to influence negative emotionality (Caspi & Moffitt, 2006).”
Differential susceptibility to the environment: An evolutionary–neurodevelopmental theory (2011, background): “Similarly, Caspi and Moffitt (2006) determined that boys’ monoamine oxidase A genotype did not elicit maltreatment.”