Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8− Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8+ Dendritic Cells1
By J. Pooley, W. Heath, K. Shortman. Journal of Immunology, 2001
665 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/c3a00b007a820741b7699e583c7bee260bb93d62
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In Immunology
- Julie M. Curtsinger
- M. Mescher
- J. Villadangos
- Jacques Banchereau
- K. Palucka
- A. Schietinger
- P. Greenberg
Citations in the corpus
- Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens (2004, background): “As we discuss below, these DCs are also the major subset responsible for cross-presentation (11, 12, 64), providing a tantalizing though unproven link between cross-presentation and viral immunity.”
- Cutting Edge: Type I IFNs Provide a Third Signal to CD8 T Cells to Stimulate Clonal Expansion and Differentiation1 (2005, background): “The CD8 subset of murine DC that most effectively presents Ag to CD8 T cells by cross-priming (20) can produce IL-12 and IFN- in response to activating stimuli such as TLR ligands (21, 22).”
- Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens (2010, background): “The CD8 DC subset appears to be most effective at inducing Th2 responses (MaldonadoLópez et al., 1999; Pulendran et al., 1999) and processing and presenting Ag to CD4+ T cells via the MHC class II pathway (Pooley et al., 2001; Dudziak et al., 2007; Villadangos and Schnorrer, 2007).”
- Critical Role for CD103+/CD141+ Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma (2016, neutral): “Finally, in noting that CD11b DC are relatively weak in trafficking antigens to tumor dLN, we can speculate that there is a ‘‘defect’’ in this axis compared with conventional LN priming; such a defect may ultimately skew T cell responses, particularly as presentation by non-CD103 DC appears importan”