Toll receptors, CD14, and macrophage activation and deactivation by LPS.

By M. Dobrovolskaia, S. Vogel. Microbes and infection, 2002

596 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Immunology

View Paper: https://www.semanticscholar.org/paper/c38b9c40105042014abc5b11f81636ca6eaac435

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. G. Núñez

In Immunology

1. T. Kanneganti
2. G. Núñez
3. L. Franchi
4. N. Inohara
5. Peter Vandenabeele
6. Shizuo Akira
7. J. Tschopp
8. M. Lamkanfi

Citations in the corpus

• Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages (2006, background): “In contrast, prolonged exposure of macrophages to microbial ligands, including LPS, induces a state of cell refractoriness ('tolerance') to secondary TLR stimulation; tolerance is characterized by greatly diminished production of proinflammatory cytokines in vitro and in vivo”
• Optimized THP-1 differentiation is required for the detection of responses to weak stimuli (2007, methodology): “To further ensure that 5 ng/ml PMA was suffi cient for the differentiation process, we analyzed CD14 expression levels, because CD14 up-regulation by PMA has been reported to be a surface marker of macrophages [2, 24].”