Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset.

By M. Cooper, T. Fehniger, S. Turner, Ken Chen, B. Ghaheri, T. Ghayur, W. Carson, M. Caligiuri. Blood, 2001

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Human Decidual Natural Killer Cells Are a Unique NK Cell Subset with Immunomodulatory Potential (2003, background): “Recent papers demonstrate greater cytokine production capacity of CD56 bright than CD56 dim pNK cells and, thus, suggest an immunoregulatory role for the CD56 bright pNK subset ( 18 , 19).”
Natural Killer Cells: Development, Maturation, and Clinical Utilization (2018, background): “org August 2018 | Volume 9 | Article 1869 (CD56brightCD16dimNKG2A+KIR−) was proposed due to their inherent ability to produce significant amounts of IL-10, and IL-13 along with IFN-γ, TNF-α, and GM-CSF compared to that of the more substantial CD56dimCD16+ subset (58).”
Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition (2013, background): “The CD56brightCD16− NK cells, which constitute the smaller subset in peripheral blood, are more abundant in tissues and are stronger cytokine/chemokine producers when stimulated with soluble factors such as IL-12 and IL-18 (86).”