Human Decidual Natural Killer Cells Are a Unique NK Cell Subset with Immunomodulatory Potential
By L. Koopman, Hernan D. Kopcow, B. Rybalov, J. Boyson, J. Orange, F. Schatz, R. Masch, C. Lockwood, A. Schachter, P. Park and 1 more. Journal of Experimental Medicine, 2003
907 citations recorded by the source corpus.
Natural killer cells constitute 50–90% of lymphocytes in human uterine decidua in early pregnancy. Here, CD56bright uterine decidual NK (dNK) cells were compared with the CD56bright and CD56dim peripheral NK cell subsets by microarray analysis, with verification of results by flow cytometry and RT-PCR. Among the ∼10,000 genes studied, 278 genes showed at least a threefold change with P ≤ 0.001 when comparing the dNK and peripheral NK cell subsets, most displaying increased expression in dNK cells. The largest number of these encoded surface proteins, including the unusual lectinlike receptors NKG2E and Ly-49L, several killer cell Ig-like receptors, the integrin subunits αD, αX, β1, and β5, and multiple tetraspanins (CD9, CD151, CD53, CD63, and TSPAN-5). Additionally, two secreted proteins, galectin-1 and progestagen-associated protein 14, known to have immunomodulatory functions, were selectively expressed in dNK cells.
Subfields: Immunology, Reproductive Medicine
View Paper: https://www.semanticscholar.org/paper/8625efcd35cbfa70660af997e143871e8313d826
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In Immunology
Citations in the corpus
- Intraepithelial type 1 innate lymphoid cells are a unique subset of cytokine responsive interferon-γ-producing cells (2013, neutral): “TGF-b imprinting was previously observed in decidual NK cells, which are in close contact with the fetal trophoblast and presumably contribute to maternalfetal tolerance (Koopman et al., 2003).”
- Decidual NK cells regulate key developmental processes at the human fetal-maternal interface (2006, background): “More than 40% of the cells in the decidua (maternal uterine mucosa during pregnancy) are NK cells of the CD56 bright CD16 − NK subse”
- Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success (2004, background): “From gene expression studies, a case has been made that uNK cells are a distinct NK cell lineage (12), although an alternative explanation could be differentiation in the unique decidual microenvironment.”