Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits

By J. Chatterton, M. Awobuluyi, L. Premkumar, Hiroto Takahashi, M. Talantova, Y. Shin, Jiankun Cui, Shichun Tu, K. Sevarino, N. Nakanishi and 3 more. Nature, 2002

724 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c31ce932a8aa1552164613067e07c025f0fe5516

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Jie Zheng
2. J. Lynch
3. M. Trudeau

In Molecular Biology

1. J. Kemp
2. Jie Zheng
3. J. Lynch
4. J. Kew
5. M. Trudeau

Citations in the corpus

• Glutamate Receptor Ion Channels: Structure, Regulation, and Function (2010, background): “The GluN3 subunits bind glycine and do not form functional receptors alone (Chatterton et al., 2002; Yao and Mayer, 2006).”
• Handbook of ion channels (2015, background): “The GluN3 subunit also reduces Mg2+ block but reduces conductance as well (Chatterton et al., 2002).”
• Biological Psychology : Stress (2016, neutral): “The NR3 (NR3A and NR3B) subunits bind glycine, and therefore are unique in forming excitatory glycine receptors when co-expressed with NR1 (Chatterton et al., 2002).”
• Molecular structure and function of the glycine receptor chloride channel. (2004, background): “Note that glycine also directly activates a cation-selective ion channel of the excitatory glutamate receptor family (62).”
• The Role of N-Methyl-d-Aspartate (NMDA) Receptors in Pain: A Review (2003, background): “Surprisingly, in contrast to conventional NR1/NR2 receptors, coassembly of NR1 with NR3A or -3B subunits forms excitatory glycine receptors that are unaffected by glutamate or NMDA, are impermeable to calcium, and are resistant to magnesium block and NMDAR antagonists ( 13 ).”
• Ionotropic and metabotropic glutamate receptor structure and pharmacology (2005, positive): “NR1/NR3 or NR2/NR3 containing receptors), although it has been reported that NR3 subunits expressed in Xenopus oocytes along with NR1 form excitatory glycine receptors that are unaffected by glutamate or NMDA (Chatterton et al. 2002).”
• Role of Distinct NMDA Receptor Subtypes at Central Synapses (2004, background): “On the other hand, it is selectively activated by glycine (18).”